PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion

نویسندگان

  • Sebastian Seufert
  • Roland Coras
  • Christian Tränkle
  • Darius P. Zlotos
  • Ingmar Blümcke
  • Lars Tatenhorst
  • Michael T. Heneka
  • Eric Hahnen
چکیده

Today, there is increasing evidence that PPARgamma agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARgamma activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARgamma inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARgamma independent manner.

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عنوان ژورنال:
  • PPAR Research

دوره 2008  شماره 

صفحات  -

تاریخ انتشار 2008